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References: AuroVist™

 

 

 

Analysis / Comparison Studies
of AuroVist as an x-ray contrast agent

  1. Laura Nebuloni, Gisela A. Kuhn, Ralph Müller. A Comparative Analysis of Water-Soluble and Blood-Pool Contrast Agents for in vivo Vascular Imaging with Micro-CT.Academic Radiology 2013; 20:1247–1255.
    • "AuroVist 15 nm provided the highest attenuation (2.33/mm) as compared to iomeprol (1.97/mm) and ExiTron nano 12000 (1.58/mm)...AuroVist 15 nm is best suited for anatomical investigation of the vascular network."
  2. Connor A. Wathen, Nathan Foje, Tony van Avermaete, Bernadette Miramontes, Sarah E. Chapaman, Todd A. Sasser, Raghuraman Kannan, Steven Gerstler, and W. Matthew Leevy. In vivo X-Ray Computed Tomographic Imaging of Soft Tissue with Native, Intravenous, or Oral Contrast. Sensors (Basel). 2013 June; 13(6): 6957–6980.
    • Another independent study with evidence for AuroVist-15 nm as the best contrast agent for vascular imaging.
  3. Hrvoje Lusic and Mark W. Grinstaff. X-ray-Computed Tomography Contrast Agents. Chem. Rev. 2013, 113, 1641-1666.
    • On AuroVist™ 1.9 nm: "The AuNPs show significant CT image enhancement as compared to iohexol contrast agent (trade name Omnipaque). Excellent tumor image enhancement is also obtained due to nanoparticle extravasation across tumor capillary pores. Such small NPs show a much higher diffusion coefficient than larger NPs. Several additional studies using these same nanoparticles show the potential of using AuNP in X-ray cancer radiotherapy (RT)."
  4. Assessing the toxicity of gold nanoparticles in vitro and in vivo Y Pan-Bartneck - 2011 - darwin.bth.rwth-aachen.de
    • "...All results consistently proved that, with similar size, the thiol modified AuNPs (Au1.1GSH and Aurovist) were nontoxic in respect to acute, cardiac and embryonic toxicity..."
  5. Hainfeld, J. F.; Slatkin, D. N.; Focella, T. M, and Smilowitz, H. M.: Gold nanoparticles: a new X-ray contrast agent. Br. J. Radiol., 79, 248-253 (2006).

 

AuroVist Catalog Information | Technical Help | Product Instructions

 

Angiogenesis / Aneurysm / Tumor Imaging

  1. Liu J, Fan W, Liu M, Lin X, Wang Y, Wang F, Chen X, Cao F, Liang J. Spatial Vascular Volume Fraction Imaging for Quantitative Assessment of Angiogenesis. Mol Imaging Biol. 2013 Oct 25.
    • AuroVist™ 15 nm used for contrast in a month-long series of in vivo micro-CT scans, chronicling angiogenesis in an ischemia model. Use of a combined micro-CT / bioluminescent tomography (BLT) imaging system allowed implanted mesenchymal stem cells (AD-MSC) to be tracked alongside angiogenesis data. In vivo vascular casting with AuroVist™ was positively confirmed by traditional ex vivo vascular casting.
  2. Bols, J., Degroote, J., Trachet, B., Verhegghe, B., Segers, P., Vierendeels, J. A computational method to assess the in vivo stresses and unloaded configuration of patient-specific blood vessels. Journal of Computational & Applied Mathematics. July 2013, Vol. 246, p10-17.
    • Dr. Trachet and his colleagues have added another computational tool to the analysis of aortic aneurysm, pioneering a method to compute the initial stress distribution present in a scanned aneurysm, thus accounting for the stresses present in a scanned geometry due to the in vivo blood pressure. They again used intravenous injection of AuroVist™ 15 nm to achieve high-resolution 3D images of AAA in a mouse model, upon which their computational backward displacement method was successfully performed to determine the unloaded geometry, which was then used to recover the scanned geometry, but this time including its initial stress distribution . Their contribution allows for a more correct computational analysis of mouse-specific stresses based on geometries obtained from in vivo scans, and may be an important step toward a more accurate understanding of the pathophysiology of cardiovascular disease.
  3. Clark, D. P.; Ghaghada K.; Moding E. J.; Kirsch D. G., and Badea, C. T.: In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. Phys. Med. Biol., 58, 1683-1704 (2013).
    • AuroVist™ 15 nm and iodine used to visualize cancer growth using dual-energy CT scans.
  4. SJ Tu, PY Yang, JH Hong, CJ Lo. Quantitative dosimetric assessment for effect of gold nanoparticles as contrast media on radiotherapy planning. Radiation Physics and Chemistry, 2013.
    • Imaging tumors with AuroVist™ to better plan radiation therapy.
  5. James F Hainfeld, Henry M Smilowitz, Michael J O'Connor, Farrokh Avraham Dilmanian & Daniel N Slatkin. Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Nanomedicine October 2013, Vol. 8, No. 10, Pages 1601-1609.
    • Theranostics: Successful imaging and treatment of brain tumors in mice using AuroVist to enhance radiation therapy.
  6. Ricketts, K.P.M.; (2012) Nanoparticles for tumour diagnostics. Doctoral thesis, UCL (University College London).
    • A novel method for detecting cancer cells missed by conventional means; both AuroVist™ 15 and 1.9 nm were used.
  7. Trachet, B.; Renard, M.; de Santis, G.; Staelens, S.; de Backer, J.; Antiga, L.; Loeys, B., and Segers, P.: An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiothensin II-infused ApoE-/- Mice. Ann. Biomed. Eng., 39, 2430–2444 (2011).
    • Abdominal aortic aneurysm (AAA) is a hidden threat, lurking behind an asymptomatic progression. Here, a potential key to predicting the disease was investigated: hemodynamics. Using non-toxic AuroVist™ as an x-ray contrast agent for micro-CT, the group created detailed 3D images of the aorta in a mouse model over time, tracking aneurysms as they formed. Points of blood flow turbulence in the aorta, calculated with the help of ultrasound scans, were found to have qualitative correlation to areas where aortic bulging later occurred. "We cannot exclude that hemodynamics play a role in the initial phases of AAA formation," the group concluded. Crucially, the group has defined an experimental-computational framework for future study of the disease and its elusive developmental factors in mice, and a better understanding of this disease may someday provide a way to identify individuals most at risk for this life-threatening condition.

 

AuroVist Catalog Information | Technical Help | Product Instructions

 

Gold Enhanced Radiation Therapy (Cancer Treatment)

  1. James F Hainfeld, Henry M Smilowitz, Michael J O'Connor, Farrokh Avraham Dilmanian & Daniel N Slatkin. Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Nanomedicine October 2013, Vol. 8, No. 10, Pages 1601-1609.
    • Successful treatment of brain tumors in mice using AuroVist to enhance radiation therapy.
  1. James F Hainfeld, F Avraham Dilmanian, Zhong Zhong, Daniel N Slatkin, John A Kalef-Ezra and Henry M Smilowitz. Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma. 2010 Phys. Med. Biol. 55 3045.
  2. Hainfeld, J. F., Slatkin, D. N., and Smilowitz, H. M.: The use of gold nanoparticles to enhance radiotherapy in mice. Phys. Med. Biol., 49, N309-N315 (2004).

 

AuroVist Catalog Information | Technical Help | Product Instructions

 

In Vivo Vascular Casting

  1. Liu J, Fan W, Liu M, Lin X, Wang Y, Wang F, Chen X, Cao F, Liang J. Spatial Vascular Volume Fraction Imaging for Quantitative Assessment of Angiogenesis. Mol Imaging Biol. 2013 Oct 25.
    • AuroVist™ 15 nm used for contrast in a month-long series of in vivo micro-CT scans, chronicling angiogenesis in an ischemia model. Use of a combined micro-CT / bioluminescent tomography (BLT) imaging system allowed implanted mesenchymal stem cells (AD-MSC) to be tracked alongside angiogenesis data. In vivo vascular casting with AuroVist™ was positively confirmed by traditional ex vivo vascular casting.
  2. Bols, J., Degroote, J., Trachet, B., Verhegghe, B., Segers, P., Vierendeels, J. A computational method to assess the in vivo stresses and unloaded configuration of patient-specific blood vessels. Journal of Computational & Applied Mathematics. July 2013, Vol. 246, p10-17.
    • Dr. Trachet and his colleagues have added another computational tool to the analysis of aortic aneurysm, pioneering a method to compute the initial stress distribution present in a scanned aneurysm, thus accounting for the stresses present in a scanned geometry due to the in vivo blood pressure. They again used intravenous injection of AuroVist™ 15 nm to achieve high-resolution 3D images of AAA in a mouse model, upon which their computational backward displacement method was successfully performed to determine the unloaded geometry, which was then used to recover the scanned geometry, but this time including its initial stress distribution . Their contribution allows for a more correct computational analysis of mouse-specific stresses based on geometries obtained from in vivo scans, and may be an important step toward a more accurate understanding of the pathophysiology of cardiovascular disease.
  3. Trachet, B.; Renard, M.; de Santis, G.; Staelens, S.; de Backer, J.; Antiga, L.; Loeys, B., and Segers, P.: An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiothensin II-infused ApoE-/- Mice. Ann. Biomed. Eng., 39, 2430–2444 (2011).
    • Abdominal aortic aneurysm (AAA) is a hidden threat, lurking behind an asymptomatic progression. Here, a potential key to predicting the disease was investigated: hemodynamics. Using non-toxic AuroVist™ as an x-ray contrast agent for micro-CT, the group created detailed 3D images of the aorta in a mouse model over time, tracking aneurysms as they formed. Points of blood flow turbulence in the aorta, calculated with the help of ultrasound scans, were found to have qualitative correlation to areas where aortic bulging later occurred. "We cannot exclude that hemodynamics play a role in the initial phases of AAA formation," the group concluded. Crucially, the group has defined an experimental-computational framework for future study of the disease and its elusive developmental factors in mice, and a better understanding of this disease may someday provide a way to identify individuals most at risk for this life-threatening condition.
  4. Hainfeld, J. F.; Slatkin, D. N.; Focella, T. M., and Smilowitz, H. M.: In Vivo Vascular Casting. Microsc. Microanal., 11, (Suppl. 2: Proceedings); p. 1216CD (2005).

 

AuroVist Catalog Information | Technical Help | Product Instructions

 

Micro-CT Imaging

  1. Liu J, Fan W, Liu M, Lin X, Wang Y, Wang F, Chen X, Cao F, Liang J. Spatial Vascular Volume Fraction Imaging for Quantitative Assessment of Angiogenesis. Mol Imaging Biol. 2013 Oct 25.
    • AuroVist™ 15 nm used for contrast in a month-long series of in vivo micro-CT scans, chronicling angiogenesis in an ischemia model. Use of a combined micro-CT / bioluminescent tomography (BLT) imaging system allowed implanted mesenchymal stem cells (AD-MSC) to be tracked alongside angiogenesis data. In vivo vascular casting with AuroVist™ was positively confirmed by traditional ex vivo vascular casting.
  2. Laura Nebuloni, Gisela A. Kuhn, Ralph Müller. A Comparative Analysis of Water-Soluble and Blood-Pool Contrast Agents for in vivo Vascular Imaging with Micro-CT.Academic Radiology 2013; 20:1247–1255.
    • "AuroVist 15 nm provided the highest attenuation (2.33/mm) as compared to iomeprol (1.97/mm) and ExiTron nano 12000 (1.58/mm)...AuroVist 15 nm is best suited for anatomical investigation of the vascular network."
  3. Bols, J., Degroote, J., Trachet, B., Verhegghe, B., Segers, P., Vierendeels, J. A computational method to assess the in vivo stresses and unloaded configuration of patient-specific blood vessels. Journal of Computational & Applied Mathematics. July 2013, Vol. 246, p10-17.
    • Dr. Trachet and his colleagues have added another computational tool to the analysis of aortic aneurysm, pioneering a method to compute the initial stress distribution present in a scanned aneurysm, thus accounting for the stresses present in a scanned geometry due to the in vivo blood pressure. They again used intravenous injection of AuroVist™ 15 nm to achieve high-resolution 3D images of AAA in a mouse model, upon which their computational backward displacement method was successfully performed to determine the unloaded geometry, which was then used to recover the scanned geometry, but this time including its initial stress distribution . Their contribution allows for a more correct computational analysis of mouse-specific stresses based on geometries obtained from in vivo scans, and may be an important step toward a more accurate understanding of the pathophysiology of cardiovascular disease.
  4. Connor A. Wathen, Nathan Foje, Tony van Avermaete, Bernadette Miramontes, Sarah E. Chapaman, Todd A. Sasser, Raghuraman Kannan, Steven Gerstler, and W. Matthew Leevy. In vivo X-Ray Computed Tomographic Imaging of Soft Tissue with Native, Intravenous, or Oral Contrast. Sensors (Basel). 2013 June; 13(6): 6957–6980.
    • Another independent study with evidence for AuroVist-15 nm as the best contrast agent for vascular imaging.
  5. Hrvoje Lusic and Mark W. Grinstaff. X-ray-Computed Tomography Contrast Agents. Chem. Rev. 2013, 113, 1641-1666.
    • On AuroVist™ 1.9 nm: "The AuNPs show significant CT image enhancement as compared to iohexol contrast agent (trade name Omnipaque). Excellent tumor image enhancement is also obtained due to nanoparticle extravasation across tumor capillary pores. Such small NPs show a much higher diffusion coefficient than larger NPs. Several additional studies using these same nanoparticles show the potential of using AuNP in X-ray cancer radiotherapy (RT)."
  6. Trachet, B.; Renard, M.; de Santis, G.; Staelens, S.; de Backer, J.; Antiga, L.; Loeys, B., and Segers, P.: An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiothensin II-infused ApoE-/- Mice. Ann. Biomed. Eng., 39, 2430–2444 (2011).
    • Abdominal aortic aneurysm (AAA) is a hidden threat, lurking behind an asymptomatic progression. Here, a potential key to predicting the disease was investigated: hemodynamics. Using non-toxic AuroVist™ as an x-ray contrast agent for micro-CT, the group created detailed 3D images of the aorta in a mouse model over time, tracking aneurysms as they formed. Points of blood flow turbulence in the aorta, calculated with the help of ultrasound scans, were found to have qualitative correlation to areas where aortic bulging later occurred. "We cannot exclude that hemodynamics play a role in the initial phases of AAA formation," the group concluded. Crucially, the group has defined an experimental-computational framework for future study of the disease and its elusive developmental factors in mice, and a better understanding of this disease may someday provide a way to identify individuals most at risk for this life-threatening condition.
  7. Assessing the toxicity of gold nanoparticles in vitro and in vivo Y Pan-Bartneck - 2011 - darwin.bth.rwth-aachen.de
    • "...All results consistently proved that, with similar size, the thiol modified AuNPs (Au1.1GSH and Aurovist) were nontoxic in respect to acute, cardiac and embryonic toxicity..."
  8. Hainfeld, J. F.; Slatkin, D. N.; Focella, T. M, and Smilowitz, H. M.: Gold nanoparticles: a new X-ray contrast agent. Br. J. Radiol., 79, 248-253 (2006).

 

AuroVist Catalog Information | Technical Help | Product Instructions

 

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