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FluoroNanogold™: Correlative labeling with fluorescence and the atmospheric scanning electron microscope (ASEM)

A cutting-edge technique opens a window on the mechanics behind cellular dynamics, with the help of a combined label for both fluorescence and electron microscopy.

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Hirano, K.; Kinoshita, T.; Uemura, T.; Motohashi, H.; Watanabe, Y.; Ebihara, T.; Nishiyama, H.; Sato, M.; Suga, M.; Maruyama, Y.; Tsuji, N. M.; Yamamoto, M.; Nishihara, S., and Sato, C.: Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM. Ultramicroscopy (2013 Oct 22): in press.

The Sato lab explores the mechanism behind cellular dynamics, using correlative microscopy with fluorescence and the atmospheric scanning electron microscope (ASEM). The group used the dual-modality probe FluoroNanogold™ to label structures of interest with both a fluorescent probe and a tightly bound gold immunolabel for EM visualization. GoldEnhance™ was used to enlarge the probes with gold, making ultrastructures even more easily visible by backscatter detection in the SEM.

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