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Curing Cancer with Magnetic Nanoparticles

Nanoprobes scientists are curing cancer in mice with magnetic nanoparticles, after a single, three-minute treatment.

Their results have just been published in the International Journal of Nanomedicine.

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Read the scientific paper online, available free (open access):
Intravenous magnetic nanoparticle cancer hyperthermia
Huang HS, Hainfeld JF. International Journal of Nanomedicine. 2013:8, 2521-2532.

Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.

Read complete paper online

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