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Nanoprobes: Nanoparticle Technology for Imaging, Microscopy and Biodetection
Updated: October 12, 2024
Nanoprobes will be closed on Monday, October 14, 2024 in recognition of the US Indigenous Peoples' Day and Columbus Day holidays. We will return to our regular business hours (8:30 AM - 5:00 PM Eastern Time) on Tuesday, October 15, 2024. If you have any questions or need to contact us, email customer service or technical support and will respond as soon as we return.
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Introducing: 5 nm Nanogold® Labeling Reagents
The power and versatility of our 1.4 nm Nanogold® labeling reagents: now in a 5 nm size.
Meet the newest addition to our family of gold nanoparticle labeling reagents.
Now available: our 5 nm Nanogold® labeling reagents bring the same covalent labeling and conjugation reactions available with our 1.4 nm Nanogold® labeling reagents.
Make any molecule a gold probe:
- Antibodies
- Proteins
- Peptides
- Oligonucleotides - DNA, RNA and PNA
- Small molecules
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- Hormones
- Surfaces
- Nanostructured materials
- ...and many more
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VivoVist™: The Ultimate Micro CT Contrast Agent |
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| Best Performance · Best Value · Best Price
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- VivoVist™ provides approximately 3-4 times higher contrast than competing commercial microCT contrast agents
- Long blood half-life of 14 hrs. Enables extended imaging times and longer diffusion into tumors and other features of interest
- Lowest price - affordable rat imaging! Less than two vials provides good contrast in a 250 g rat.
- Low toxicity (4 g/kg is well-tolerated). Produce super-high contrst in fine structures and accelerate loading of tumors
- Low osmolality, even at high concentrations - minimal metabolic disruption
- Low viscosity: easy to inject into small mouse tail vein blood vessels
- Image with MicroCT, clinical CT, planar X-ray, or mammography units - flexibility for any desired instrument configuration
- Enhances radiotherapy - higher X-ray dose to tumors and other targets
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Featured Application: Western Blotting
Detect His-tagged or native proteins quickly and easily with high sensitivity
- GoldiBlot™ detects His-tagged recombinant proteins. Binding strength comparable to antibodies, fast development and consistent performance. No antibodies required: procedure complete in 1 hour 15 minutes. Learn more
- EnzMet™ provides super-sensitive detection of native, unmodified proteins: just replace DAB or other organic chromogens in almost any peroxidase-based procedure. Learn more
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The Power of
FluoroNanogold™
comes to Super-Resolution!
2-in-1 Labels for
BOTH Super-Res and TEM
See your target in its cellular context!
- Alexa Fluor® 647 dye for Super-Res (STORM)
- PLUS Nanogold® particles for visibility in TEM
- Covalently bound for stability, long working times
- Convenient secondary antibody/Fab' or streptavidin
- Get both in a single, standard labeling procedure
- Easy kits to enhance for light/phase microscopy
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Updates
Our mission at Nanoprobes is to harness chemistry, biology and nanotechnology to engineer the most sensitive reagents and nanotechnology for detecting, locating and visualizing biological molecules.
Our unique gold nanoparticle labeling technology uses chemically cross-linked metal clusters and nanoparticles as labels.
Unlike conventional immunogold probes, in which colloidal gold particles are electrostatically adsorbed to antibodies and proteins, our gold nanoparticle labels are uncharged molecules which are cross-linked to specific sites on biomolecules. This gives our nanogold probes greater range and versatility than colloidal gold.
Our labels can be attached to any molecule with a reactive group -- proteins, peptides, oligonucleotides, small molecules and lipids -- for detection and localization. Other labels can be combined with our gold particle labels; our unique FluoroNanogold probes combine Nanogold® and fluorescein into a single probe for imaging a specimen both by fluorescence and electron microscopy. Our gold nanoparticles, including our Nanogold™ conjugates, and Nanogold™ labeling reagents, are formulated for use with electron microscopy (tem) as well as light microscopy, immunolabeling, x-ray contrast for EM, angiography, mammography and microCT, and for correlative and fluorescence microscopy imaging.
New probes can be engineered based on any fragment of a naturally occurring biomolecule, and the label can be positioned away from the binding site so it does not interfere with binding.
Our Nanogold® probes have been cited in over 250 publications, and are used in the laboratories of several Nobel Laureates.
It's all about creating better tools and finding innovative solutions, so that research and treatments can move ahead.
Drop us a line and let us know what you're working on. We'll be glad to help.
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Nanoprobes, Inc.
95 Horseblock Road, Unit 1
Yaphank, NY 11980-9710
USA |
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