VivoVist™ is a revolutionary new X-ray contrast agent from Nanoprobes. It enables higher contrast than competing agents, at a lower price that makes imaging in rats or other larger animals affordable for the first time.
Best Performance · Best Value · Best Price
Head of an anesthetized adult 25 g mouse imaged by microCT following intravenous delivery of VivoVist (250 ul).
In vivo imaging performed with a Bruker SkyScan1276 system at 13 um voxels resolution. 3D image was generated and analyzed with Horos v4.0.0. Brain vessels of 50 microns or smaller were resolvable. Image kindly provided by Dr. Sean Marrelli, Department of Neurology at the McGovern Medical School at UTHealth (Houston, TX).
VivoVist™ provides approximately 3-4 times higher contrast than competing commercial microCT contrast agents. An Initial blood concentration of 50 mg/mL (5%), or 1 g/kg body weight (one-third of one vial for a 25 g mouse) gives greater than 3500 HU (Hounsfeld Units) contrast.
Long blood half-life of 14 hrs. VivoVist™ stays in the circulatory system longer than competing products. This enables extended imaging times and data collection, and allows longer diffusion into tumors and other features of interest, increasing their contrast.
Lowest price - makes imaging rats and larger animals affordable. VivoVist™ is more concentrated that competing products, meaning that fewer units are required to image larger animals. Less than two vials will provide good contrast in a 250 g rat.
Low toxicity (4 g/kg is well-tolerated). VivoVist™ can be administered in higher doses than competing products, to produce super-high contrst in fine structures or to accelerate loading of tumors or other features of interest.
Low osmolality, even at high concentrations. This means that injecting VivoVist™ will not greatly change the levels of electrolytes in the circulatory system. Impacts to metabolism, signaling and other processes that depend on maintaining a steady ionic strength are minimized.
Low viscosity: easy to inject into small mouse tail vein blood vessels (typical injection volume 0.25 mL). VivoVist™ is more easily injected, causes less injection site trauma to the animal, and may be administered more quickly and in higher concentration that more viscous contrast agents such as iodine-based reagents.
Can be imaged using MicroCT, clinical CT, planar X-ray, or mammography units. VivoVist™ is adaptable for any commonly used computed tomography system, giving users the flexibility to image in any desired instrument configuration.
Enhances radiotherapy X-ray dose to tumors and other targets. Because it absorbs X-rays so strongly, VivoVist™ increases the local X-ray dose. If it is concentrated in tumors or other therapeutic targets, it can provide a method for enhancing radiotherapy and increasing the efficacy of cancer therapy.
Live mouse microCT imaging with VivoVist™. Image taken shortly after tail vein injection of 2 g/kg VivoVist™ with a Scanco VivaCT 80. Bar = 5mm
More About VivoVist™
VivoVist™ is a revolutionary nanotechnology super contrast agent of alkaline earth metal nanoparticles. VivoVist™ enables greatly enhanced X-ray imaging of blood vessels, tumors, and other tissues and organs.
It is particularly useful for in vivo live animal microCT imaging, for studies of tumors, stroke, atherosclerosis and other vascular conditions, organ function, and other biological structural and functional analyses.
VivoVist™ is priced to make micro CT affordable not just for mice but even for rats. One vial provides clear contrast for three mice (25 g each) at 1 g/kg, at a price from just $28 per mouse. In a 250 g rat, you can obtain clear contrast at 0.54 g/kg using less than two vials, for a cost of only $152.
What Your Collegues are Saying about VivoVist™
“We are truly impressed by the quality of the new CT contrast agent VivoVist. VivoVist is one of the brightest CT contrast agents we have used, with a long circulation time in the blood and minimal toxicity to the injected animals.”
--Shili Xu, Ph.D. Assistant Professor, Director, Crump Institute Preclinical Imaging Technology Center, UCLA, CA.
"We thought it was great. In fact I've been having other labs using our scanner order it. Great product. works well IP as well for liver met detection. We will be ordering more soon!!"
--Patrick J. Worth, M.D., FACS, FSSO, surgeon-scientist, Oregon Health and Science University, Portland, OR.
“VivoVist™ remarkably improves micro-CT imaging, demonstrating high contrast enhancement and offering a great solution for high quality scans.”
--Cristian Badea, PhD, Professor in Radiology, Duke University, Durham, NC.
"The contrast worked great and I placed an order. It's very bright and it's much less viscous compared to the Fenestra so it was much easier for me to perform tail vein injections."
--Minh Ma, cancer immunotherapy researcher, Rutgers New Jersey Medical School
" VivoVist is a multiple-purpose CT contrast agent; it is good for cardiac, hepatocellular, kidney, spleen, and so on. It's easy to inject, and its biological half-life is long too"
Live mouse microCT image taken shortly after tail vein injection of 2g/kg VivoVist™ with a Scanco VivaCT 80 at 70kVp. From the top view (with spine at top), organs and structures visualized include the inferior vena cava (bright vessel near spine), hepatic artery (largest bright vessel); blood vessels in the liver; spleen (tubular structure on right). Back view (with spine vertical) shows blood supply to the two kidneys (in the mouse the kidney is about the size of a kidney bean), with the spleen on the lower right.
Compare Key Features and Prices
Mouse (25 g) - Good Contrast (1 g/kg of VivoVist™)
Contrast Agent (Element)
Injection Volume (mL)
Blood Half-Life (h)
Price (USD)
VivoVist™
0.08
14
$28
Exitron Nano 12000
0.09
4
$112
Exitron P
0.25
~1
$255
Fenestra VC
0.50*
~1
$81
*injection volume very high
Mouse (25 g) - Super Contrast (3 g/kg of VivoVist™)
Contrast Agent (Element)
Injection Volume (mL)
Blood Half-Life (h)
Price (USD)
VivoVist™
0.25
14
$84
Exitron Nano 12000
0.09
4
$112
Exitron P
0.25
~1
$255
Fenestra VC
0.50*
~1
$81
*injection volume very large
Rat (250 g) - good contrast (0.54 g/kg of VivoVist™)
Contrast Agent (Element)
Injection Volume (mL)
Blood Half-Life (h)
Price (USD)
VivoVist™
0.45
14
$152
Exitron Nano 12000
0.50
4
$510
Exitron P
0.75
~1
$765
Contrast agent
1.20*
~1
$194
*injection volume too large for mouse
Price and Ordering Information: VivoVist™ Alkaline Earth Metal X-ray Contrast Agent
International orders:Our regional distributors can provide expedited customs processing and delivery.
