Gold Lipid Conjugates
with 1.4 nm Nanogold® or 0.8 nm Undecagold

Each lipid molecule is covalently linked to a Nanogold® or undecagold cluster through its polar head group. Since the gold moiety is hydrophilic, these molecules retain the amphiphilic nature of the parent lipid, and behave like fatty acids or phospholipids.

Study membranes by incorporation into the lipid phase, or gold-label micelles and vesicles so that they can be identified and visualized.

• Discrete single molecules with one lipid to one gold cluster label.
• Covalent attachment ensures consistent structure and properties.
• Stable, long shelf life.
• Soluble in organic solvents and alcohols for easy incorporation into liposomes.
• Visualize directly by EM
  or use silver enhancement or gold enhancement to see by eye or LM
• Available with 1.4 nm Nanogold® or 0.8 nm undecagold

Applications

• Follow liposomal transport or drug delivery by EM or LM



Schematic showing the pathways of Nanogold®-labeled liposomes in cells, as revealed by EM. Ambisome is a channel-forming anti-fungal drug: in its absence, the pattern of the label as revealed by silver enhancement shows that the liposome fuses with the cell membrane (left), but when it is present, the liposomes enter the cell (right) and Nanogold® accummulates in the cytoplasm (Adler-Moore, J.; Bone Marrow Transplantation, 14, S3-S7 (1994)).

• Prepare novel arrays and nanostructures
  using the phase properties of labeled liposomes.
• Use silver enhancement or gold enhancement
  for a highly visible, permanent signal in lipoimmunoassays.

References

Price List: Gold Lipids Custom labeling is also available for other lipids and related molecules. #4020-30NMOL Palmitoyl Nanogold® The C15 palmitic acid (a fatty acid) covalently attached to the 1.4 nm Nanogold® particle. 30 nmol $514 Qty: Code (Optional) #4021-30NMOL DPPE Nanogold® Dipalmitoyl phosphatidylethanolamine covalently attached to the 1.4 nm Nanogold® particle. 30 nmol $564 Qty: Code (Optional) #4022-30NMOL Palmitoyl Undecagold The C15 palmitic acid (a fatty acid) covalently attached to the 0.8 nm Nanogold® particle. 30 nmol $445 Qty: Code (Optional) #4023-30NMOL DPPE Undecagold Dipalmitoyl phosphatidylethanolamine covalently attached to the 0.8 nm undecagold particle. 30 nmol $487 Qty: Code (Optional) International orders: Our regional distributors can provide expedited customs processing and delivery.

Technical Information