Frederic R. Furuya, PhD
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Fred is one of the founders of Nanoprobes, and has worked at the Company since February 1994. He has a Ph.D. in organometallic chemistry from the University of Minnesota at Minneapolis and B.S. in chemistry from Brown University, Providence, RI. He directs the preparation of many of the items in our catalog, especially the colloidal gold conjugates: if you have a technical question about these, Fred is the best person to answer it.
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E-mail Fred at frfuruya@nanoprobes.com
Recent publications
Research Interests
Ultrasensitive Biosensors
In addition to their electron microscope visibility and ability to nucleate silver enhancement, gold cluster complexes possess other unique electronic and physical properties which could potentially form the basis for ultrasensitive detection methods and biosensors. Our research is direscted towards characterizing some of these properties, and developing the synthetic chemistry for incorporating these labels into systems such as electronic sensors and switches and biosensors.
Incorporation of labels into biopolymers
Because our probe labels are linked covalently, they can potentially be incorporated into any molecule with a suitable reactive chemical group. For example, gold clusters can be inserted into synthetic peptides and oligonucleotides during solid-phase synthesis by using gold-labeled monomers. This opens up numerous possibilities, such as incorporating highly visible tags selectively into combinatorial arrays, or the direct synthesis of labeled in situ hybridization probes.
- "DNA Nanowires:" Hainfeld, J. F.; ; Furuya, F. R.; Powell, R. D., and Liu, W.; Microsc. Microanal., 7, (Suppl. 2: Proceedings) (Proceedings of the Fifty-Ninth Annual Meeting, Microscopy Society of America); Bailey, G. W.; Price, R. L.; Voelkl, E., and Musselman, I. H., Eds.; Springer-Verlag, New York, NY, 1034-1035 (2001).
- "Gold Cluster Crystals:" Hainfeld, J. F.; Furuya, F. R., and Wall, J. S.; Microsc. Microanal., 6, (Suppl. 2: Proceedings) (Proceedings of the Fifty-Eighth Annual Meeting, Microscopy Society of America); Bailey, G. W.; McKernan, S; Price, R. L.; Walck, S. D.; Charest, P.-M., and Gauvin, R., Eds.; Springer-Verlag, New York, NY, 326-327 (2000).
- "Greengold, a giant cluster compound of unusual eletronic structure:" Gutierrez, E.; Powell, R. D.; Furuya, F. R.; Hainfeld, J. F.; Schaaf, T. G.; Shafigullin, M. N.; Stephens, P. W., and Whetten, R. L.; Eur. J. Phys., D., 9, 647-651 (1999).
- "Metallosomes:" Hainfeld, J. F.; Furuya, F. R., and Powell, R. D.; J. Struct. Biol., 127, 152-160 (1999).
- "Dual-Labeled probes for fluorescence and electron microscopy:" Powell, R. D.; Halsey, C. M. R.; Gutierrez, E.; Hainfeld, J. F., and Furuya, F. R.; Proc. 56th Ann. Mtg., Micros. Soc. Amer.; Bailey, G. W.; Alexander, K. B.; Jerome, W. G.; Bond, M. G., and McCarthy, J. J., Eds.; Springer, New York, NY, 1998, p. 992.
- Hainfeld, J.F. and Furuya, F.R. Silver enhancement of Nanogold and undecagold. In M.A. Hyat (Ed.), Immunogold silver staining: Principles, Methods and Applications. M. A. Hayat. Ed.; CRC Press, Boca Raton, pp. 72-91 (1995).
- Hainfeld, J. F., and Furuya, F. R. Aldehyde Gold Clusters for Molecular Labeling. Proc. 53rd Ann. Mtg., Micros. Soc. Amer.; Bailey, G. W., Ellisman, M. H., Hennigar, R. A., and Zaluzec, N. J. (Eds.); Jones and Begell, New York, NY, 1995, pp. 858-859.
- Braig, K., Simon, M., Furuya, F., Hainfeld, J.F., and Horwich, A.L. A polypeptide bound by the chaperonin groEL is localized within a central cavity. Proc. Natl. Acad.Sci., 90, 3978-3982 (1993).
- Hainfeld, J.F. and Furuya, F.R. A 1.4nm Gold cluster covalently attached to antibodies improves immunolabeling, J. Histochem. Cytochem., 40, 177-184 (1992).
- Furuya, F. R., Hainfeld, J. F., and Powell, R. D. A New 1.4 nm Gold-Fab probe. Proc. 49th Ann. Mtg., Micros. Soc. Amer.; Bailey, G. W., and Hall, E. L. (Eds.); San Francisco Press, San Francisco, CA, 1991, pp.286-287.
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